{"id":675,"date":"2017-09-04T16:13:12","date_gmt":"2017-09-04T09:13:12","guid":{"rendered":"https:\/\/simenteknindo.com\/news\/?p=675"},"modified":"2017-09-04T16:13:12","modified_gmt":"2017-09-04T09:13:12","slug":"rd-center-finds-room-for-condition-monitoring","status":"publish","type":"post","link":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/","title":{"rendered":"R&#038;D Center Finds Room for Condition Monitoring"},"content":{"rendered":"<div id=\"awbs-main-content\" class=\"row\">\n<div class=\"col-md-12 awbs-body-text short\">\n<p>Though some industries and companies lag in R&amp;D, the pharmaceutical industry isn\u2019t one of them. New R&amp;D is a vital ingredient for company longevity in this industry, along with manufacturing innovation.<\/p>\n<p>Recently, the pharmaceutical giant Boehringer Ingelheim built a new research center that produces small batches of active pharmaceutical ingredients (APIs) for clinical studies. The 29,000 sq ft R&amp;D center in Biberach, Germany, employs a condition monitoring approach for inert gases being added to process tanks at variable levels of pressure.<\/p>\n<p>The production of active ingredients involves flammable solvents with reactors, centrifuges and dry cabinets. Though many different gases are used, nitrogen and argon play a large role at the research facility.<\/p>\n<section id=\"block-block-70\" class=\"block block-block clearfix\"><\/section>\n<p>Before the new research center was built, the regulation of inert gases was a manual operation. Operators also manually adjusted regulating pneumatic valves and relied completely on a closed-loop control system. After meeting with Festo, Boehringer Ingelheim determined it wanted more automation and condition monitoring for this unique pharmaceutical ingredient application.<\/p>\n<section id=\"block-dfp-native\" class=\"block block-dfp clearfix\"><\/section>\n<p>According to Boehringer Ingelheim, the company \u201cwanted to have higher flexibility\u2014due to many (quick) changeovers\u2014and overall better monitoring of this process.\u201d The research center produces many small batches for clinical studies, with reactors capable up to 1 cubic meter or 1,000 L.<\/p>\n<p>Though it was paying for production flexibility, the pharma giant wasn\u2019t overly concerned with a quick return on investment due to lower device costs, quick commissioning and better operational efficiencies, according to Festo.<\/p>\n<p>The previous clinical production design included three pressure levels to regulate argon and nitrogen, each with its own piping network, control valves and flowmeters. The new setup now uses Festo\u2019s VPPM proportional pressure regulators that integrate into an MPA valve terminal and connect to a CPX automation platform. While these regulators offer multi-sensor control via two pressure sensors, this open-loop control platform communicates with a Siemens PCS-7 plant system for set-point values.<\/p>\n<p>The new design has two reactors per room, and one inert gas station connects to both. Each container has one valve for argon and two for nitrogen. The first pressure valve elicits a range of 0-2 bars and the second has a pressure range of 0-6 bars. For this new design, Boehringer Ingelheim removed the flow sensors from the piping at the reactor and moved them to the control cabinet. The sensors are now connected to a 15-bit analog input module on the CPX automation platform and provide continuous monitoring via pressure switch at the central pressure reducer.<\/p>\n<p>In another production sequence for the APIs, proportional valves are used for the mechanical seals of the agitators\u2014or mixers. This inert gas station includes a proportional valve, flowmeter and a micro filter. The extra costs incurred by an additional flowmeter are offset by better control and monitoring of the integrated automation platform.<\/p>\n<p>\u201cBoehringer Ingelheim has a few more monitoring possibilities now, with the automated gas supply for the gaskets for the mixer,\u201d says Thomas Schulz, head of industry segment for biotech\/pharma\/cosmetics at Festo. \u201cWith the manual operation in the previous facility, operators could not follow all of the pressure in the bearing.\u201d<\/p>\n<p>The pressure for the mixing application needs to be a least 2 bars higher than the pressure in the vessel where the ingredients are mixed. With the older design, operators were regulating the pressure and flow toward the gasket according to the highest values needed during the whole process, according to Festo.<\/p>\n<p>\u201cNow, whenever there\u2019s a pressure change in the vessel, the valve platform\u2019s automation adjusts the pressure in the gasket to meet the right specification,\u201d Schulz says. \u201cIn the past, once a year, operators would disassemble the bearing to check on its health.\u201d<\/p>\n<p>Now, operators can monitor how much nitrogen consumption is going to the gasket and avoid a bearing check on the gaskets for the mixer. The integration with the plant\u2019s central control systems allows for a condition monitoring maintenance approach for the gaskets.<\/p>\n<p>The design uses the Profinet protocol to communicate with the MPA valve terminal to the plant process control system via the CPX automation module and integrated bus node.<\/p>\n<p>Another advantage with the valve terminal technology is the control cabinet. Boehringer Ingelheim moved the compact platform into the control cabinet in a technology corridor outside the reactor rooms or a non-atmospheric explosion (ATEX) area. The old plant design had the control valves, positioners and flowmeters in the ATEX zone.<\/p>\n<p>Now, because of the integration of the mechanical seal in the inert gas station, eight proportional valves reside in the control cabinet.<\/p>\n<p>This compact platform offering is just another example of global companies investing in low-cost automation for better operational efficiencies. For this pharmaceutical company, the R&amp;D spirit can be found throughout the enterprise.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Though some industries and companies lag in R&amp;D, the pharmaceutical [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":676,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,13],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>R&amp;D Center Finds Room for Condition Monitoring - SIMENTEK News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"R&amp;D Center Finds Room for Condition Monitoring - SIMENTEK News\" \/>\n<meta property=\"og:description\" content=\"Though some industries and companies lag in R&amp;D, the pharmaceutical [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/\" \/>\n<meta property=\"og:site_name\" content=\"SIMENTEK News\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/PtSimenteknindo\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-09-04T09:13:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"800\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Wimpy\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@simenteknindo\" \/>\n<meta name=\"twitter:site\" content=\"@simenteknindo\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Wimpy\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/\"},\"author\":{\"name\":\"Wimpy\",\"@id\":\"https:\/\/simenteknindo.com\/news\/#\/schema\/person\/524d37c7e448b5855c7499cd6356fa3e\"},\"headline\":\"R&#038;D Center Finds Room for Condition Monitoring\",\"datePublished\":\"2017-09-04T09:13:12+00:00\",\"dateModified\":\"2017-09-04T09:13:12+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/\"},\"wordCount\":801,\"publisher\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg\",\"articleSection\":[\"Automation News\",\"Industry News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/\",\"url\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/\",\"name\":\"R&D Center Finds Room for Condition Monitoring - SIMENTEK News\",\"isPartOf\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg\",\"datePublished\":\"2017-09-04T09:13:12+00:00\",\"dateModified\":\"2017-09-04T09:13:12+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage\",\"url\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg\",\"contentUrl\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg\",\"width\":1200,\"height\":800},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/simenteknindo.com\/news\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R&#038;D Center Finds Room for Condition Monitoring\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/simenteknindo.com\/news\/#website\",\"url\":\"https:\/\/simenteknindo.com\/news\/\",\"name\":\"SIMENTEK News\",\"description\":\"Distributor SIEMENS Indonesia\",\"publisher\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/simenteknindo.com\/news\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/simenteknindo.com\/news\/#organization\",\"name\":\"PT. SIMENTEKNINDO\",\"url\":\"https:\/\/simenteknindo.com\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/simenteknindo.com\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2016\/06\/simentek-logo.png\",\"contentUrl\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2016\/06\/simentek-logo.png\",\"width\":400,\"height\":400,\"caption\":\"PT. SIMENTEKNINDO\"},\"image\":{\"@id\":\"https:\/\/simenteknindo.com\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/PtSimenteknindo\/\",\"https:\/\/x.com\/simenteknindo\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/simenteknindo.com\/news\/#\/schema\/person\/524d37c7e448b5855c7499cd6356fa3e\",\"name\":\"Wimpy\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/simenteknindo.com\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2020\/07\/wimpy-96x96.jpg\",\"contentUrl\":\"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2020\/07\/wimpy-96x96.jpg\",\"caption\":\"Wimpy\"},\"description\":\"www.linkedin.com\/in\/wimpynf\",\"sameAs\":[\"www.linkedin.com\/in\/wimpynf\"],\"url\":\"https:\/\/simenteknindo.com\/news\/author\/wnf\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"R&D Center Finds Room for Condition Monitoring - SIMENTEK News","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/","og_locale":"en_US","og_type":"article","og_title":"R&D Center Finds Room for Condition Monitoring - SIMENTEK News","og_description":"Though some industries and companies lag in R&amp;D, the pharmaceutical [&hellip;]","og_url":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/","og_site_name":"SIMENTEK News","article_publisher":"https:\/\/www.facebook.com\/PtSimenteknindo\/","article_published_time":"2017-09-04T09:13:12+00:00","og_image":[{"width":1200,"height":800,"url":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg","type":"image\/jpeg"}],"author":"Wimpy","twitter_card":"summary_large_image","twitter_creator":"@simenteknindo","twitter_site":"@simenteknindo","twitter_misc":{"Written by":"Wimpy","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#article","isPartOf":{"@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/"},"author":{"name":"Wimpy","@id":"https:\/\/simenteknindo.com\/news\/#\/schema\/person\/524d37c7e448b5855c7499cd6356fa3e"},"headline":"R&#038;D Center Finds Room for Condition Monitoring","datePublished":"2017-09-04T09:13:12+00:00","dateModified":"2017-09-04T09:13:12+00:00","mainEntityOfPage":{"@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/"},"wordCount":801,"publisher":{"@id":"https:\/\/simenteknindo.com\/news\/#organization"},"image":{"@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage"},"thumbnailUrl":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg","articleSection":["Automation News","Industry News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/","url":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/","name":"R&D Center Finds Room for Condition Monitoring - SIMENTEK News","isPartOf":{"@id":"https:\/\/simenteknindo.com\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage"},"image":{"@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage"},"thumbnailUrl":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg","datePublished":"2017-09-04T09:13:12+00:00","dateModified":"2017-09-04T09:13:12+00:00","breadcrumb":{"@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#primaryimage","url":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg","contentUrl":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2017\/09\/1705_f4_1.jpg","width":1200,"height":800},{"@type":"BreadcrumbList","@id":"https:\/\/simenteknindo.com\/news\/rd-center-finds-room-for-condition-monitoring\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/simenteknindo.com\/news\/"},{"@type":"ListItem","position":2,"name":"R&#038;D Center Finds Room for Condition Monitoring"}]},{"@type":"WebSite","@id":"https:\/\/simenteknindo.com\/news\/#website","url":"https:\/\/simenteknindo.com\/news\/","name":"SIMENTEK News","description":"Distributor SIEMENS Indonesia","publisher":{"@id":"https:\/\/simenteknindo.com\/news\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/simenteknindo.com\/news\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/simenteknindo.com\/news\/#organization","name":"PT. SIMENTEKNINDO","url":"https:\/\/simenteknindo.com\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/simenteknindo.com\/news\/#\/schema\/logo\/image\/","url":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2016\/06\/simentek-logo.png","contentUrl":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2016\/06\/simentek-logo.png","width":400,"height":400,"caption":"PT. SIMENTEKNINDO"},"image":{"@id":"https:\/\/simenteknindo.com\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/PtSimenteknindo\/","https:\/\/x.com\/simenteknindo"]},{"@type":"Person","@id":"https:\/\/simenteknindo.com\/news\/#\/schema\/person\/524d37c7e448b5855c7499cd6356fa3e","name":"Wimpy","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/simenteknindo.com\/news\/#\/schema\/person\/image\/","url":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2020\/07\/wimpy-96x96.jpg","contentUrl":"https:\/\/simenteknindo.com\/news\/wp-content\/uploads\/2020\/07\/wimpy-96x96.jpg","caption":"Wimpy"},"description":"www.linkedin.com\/in\/wimpynf","sameAs":["www.linkedin.com\/in\/wimpynf"],"url":"https:\/\/simenteknindo.com\/news\/author\/wnf\/"}]}},"_links":{"self":[{"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/posts\/675"}],"collection":[{"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/comments?post=675"}],"version-history":[{"count":1,"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/posts\/675\/revisions"}],"predecessor-version":[{"id":677,"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/posts\/675\/revisions\/677"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/media\/676"}],"wp:attachment":[{"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/media?parent=675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/categories?post=675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/simenteknindo.com\/news\/wp-json\/wp\/v2\/tags?post=675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}